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Research Interest
My laboratory uses a wide range of techniques to investigate the molecular and genetic
mechanisms of cardiovascular disorders. My research focus is to find the functional
role of novel genes in heart. We are also elucidating the role of human gene mutation
in cardiac function and identifying genetic, biochemical, cellular and biophysical
pathways that lead from mutation to disease by using a transgenic mouse model. My
laboratory has a long-standing interest to study innate immunity of heart and to
find therapeutic strategies
to reduce cardiac injury.
Overall goal is to bridge the gap between observations in the basic research laboratory
and the clinical bedside. My studies will be an integral part in ‘‘translating’’
new discoveries into therapeutic initiatives.
Academic Qualifications
PhD, Pharmacology,
All India Institute of Medical Sciences,
New Delhi,
India, 2004
Master of Pharmacy,
Jadavpur
University
,
Kolkata, India
, 1998
Bachelor of Pharmacy,
Jadavpur
University
,
Kolkata, India
, 1996
Research Experience
Post Doctoral Associate (2005
–2009)
Cardiovascular Institute, Department of Medicine,
University of Pittsburgh
,
Pittsburgh, PA,
USA
Post Doctoral Associate (2003 –2005)
Department of Medicine,
SUNY Upstate Medical University
Syracuse, NY,
USA
Awards/Honors
·
Awarded Travel
Scholarship for research presentation in
Keystone Conference “Molecular Mechanism of Arrhythmia and Heart Failure”,
Keystone,
Colorado
, April 2-7, 2009.
·
Awarded best Postdoctoral research work at the University
of Pittsburgh Sixth Annual Department of Medicine Research Day,
May, 2008.
·
Awarded independent
Post doctoral Project from American Heart Association (July, 2007-June, 2009).
·
Selected as one and only Postdoctoral Fellow to present
at the University of Pittsburgh Fifth Annual Department of Medicine Research Day
(May 3, 2007) as a representative
of the research excellence.
·
Awarded third place in Poster Presentation in Fellow’s
Research Day organized by “American Heart Association”
Pittsburgh
, February, 2007
·
Postdoctoral Fellowship award from
Hillgrove Foundation, 2006-2007
·
Awarded Young
Scientist Project from Department of Science
& Technology (DST), Ministry of Science & Technology, Government
of India, New Delhi, India, in 2002.
·
Selected as Senior
Research Fellow from Council of Scientific
and Industrial Research, Government of India, New Delhi, India, in 1999.
·
Qualified
GATE (Graduate Aptitude Test in Engineering) in 1996 and was awarded post
graduation fellowship during post graduation from 1996 to 1998.
·
Awarded National Scholarship in class
10th standard in 1990.
Selected Publications
1.
Banerjee SK, McGaffin
KR, Ahmad F. Activation of cardiac hypertrophic signaling pathways in a transgenic
mouse with the human PRKAG2 Thr400Asn
mutation.(In-Press)
2.
Banerjee SK, McGaffin
KR, Pastor-Soler NM, Ahmad F. SGLT1 is a novel cardiac glucose transporter that
is perturbed in disease states. Cardiovasc Res.
2009; 84(1):111-118.
3.
Hanczko R,
Fernandez DR, Doherty E, Qian Y, Vas G, Niland B, Telarico T, Garba A,
Banerjee SK, Middleton FA, Barrett D, Barcza M, Banki K, Landas SK, Perl
A. Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced
liver failure in transaldolase-deficient mice by N-acetylcysteine.
J Clin Invest. 2009; 119(6):1546-1557.
4.
Fernandez DR,
Telarico T, Bonilla E, Li Q, Banerjee SK,
Middleton FA, Phillips PE,Crow MK, Oess S, Muller-Esterl W, Perl A. Activation of
mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through
HRES-1/Rab4-regulated lysosomal degradation.
Journal of Immunology. 2009;182(4):2063-73.
5.
Ahmad F, Banerjee SK, Lage ML, Huang XN, Smith
SH, Saba S, Rager J, Conner DA,
Janczewski AM, Tobita K, Tinney JP, Moskowitz
IP, Perez-Atayde AR, Keller BB, Mathier MA,
Shroff SG,
Seidman CE, Seidman JG.
The role of cardiac troponin T quantity and function in
cardiac development and dilated cardiomyopathy. PLoS
ONE 2008;3(7):e2642.
6.
Qian Y,
Banerjee SK, Grossman CE, Wendy Amidon1, Nagy G, Barcza M, Niland B, Karp DR,
Middleton FA, Banki K, Perl A. Transaldolase
deficiency influences the pentose phosphate
pathway, mitochondrial homeostasis, and apoptosis signal
processing. Biochemical Journal. 2008;
415(1):123-34.
7.
Banerjee SK, Ramani
R, Saba S, Rager J, Tian R, Mathier MA, Ahmad F. A PRKAG2 mutation causes
biphasic changes in myocardial AMPK activity and does not protect against ischemia.
Biochem. Biophys. Res. Commun. 2007 Aug
24;360(2):381-7.
8.
Perl A, Qian Y,
Chohan KR,
Shirley CR,
Amidon W,
Banerjee SK,
Middleton FA,
Conkrite KL,
Barcza M,
Gonchoroff N,
Suarez SS,
Banki K.
Transaldolase is essential
for maintenance of the mitochondrial transmembrane potential and fertility of spermatozoa.
Proc Natl Acad Sci U S A.
2006;103(40):14813-8.
9.
Banerjee SK, Sood S, Dinda
AK, Das TK, Manchanda SC, Maulik SK. Chronic oral
administration of raw garlic protects against isoproterenol-induced myocardial necrosis
in rat. Comp Biochem Physiol C Toxicol Pharmacol.
2003; 136(4):377-386.
10.
Banerjee SK, Dinda AK, Manchanda SC, Maulik SK.
Chronic garlic administration protects rat heart against
oxidative stress induced by ischemic reperfusion injury.
BMC Pharmacology. 2002, 2:16.
11.
Banerjee SK., Maulik M.,
Mancahanda SC., Dinda AK., Gupta SK., Maulik SK. Dose dependent induction of endogenous
antioxidant by chronic administration of
garlic in rat heart.
Life Sciences 2002, 70 (13): 1509-1518.
[Featured in BMC Press Release (Sept. 9,
2002) and Innovations report (Sept. 10, 2002), Breaking news in ‘Food & Drink
Europe.com’ & ‘NUTRA Ingredients.com Europe’ (Sept. 10, 2002)]
12.
Banerjee SK, Maulik M., Manchanda SC, Dinda AK, Das TK and Maulik SK. Garlic induced alteration in rat liver
and kidney morphology and associated changes in endogenous antioxidant status. Food and Chemical Toxicology 2001, 39(8):793-797.
Review Papers
13.
Banerjee SK, Mukherjee PK and Maulik SK. The antioxidant
effect of garlic. The good, the bad and the ugly.
Phytotherapy Research 2003, 17(2): 1-10.
14.
Banerjee SK, Maulik SK. Effect of garlic on cardiovascular
disorders: a review.
Nutrition Journal 2002, 1:4
[Top 10 most accessed article
from ‘Nutration Journal’ for all time since it published,
http://www.nutritionj.com/mostviewedalltime]
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