Dr.Raghavan S
Sr. Principal Scientist
CSIR-Indian Institute of Chemical Technology                             
(Council of Scientific and Industrial Research)
Ministry of Science & Technology, Government of India
Tarnaka, Hyderabad-500007, Telangana, INDIA

Landline 27191627
Mobile 9000113908
Fax
Email ID sraghavan@iict.res.in
Alternate Email ID purush101@yahoo.com
Alternate URL

Bibliography

About

Ph. D Synthetic Organic Chemistry, Indian Institute of Science, Bangalore, June 1990, Under the guidance of Prof. G. S. R Subba Rao. Thesis title: Synthetic studies on Morellin.

Published ca. 72 papers in peer reviewed journals.

Education

B.Sc. Chemistry & Zoology, Madura college, Madurai, May 1983

M.Sc. Organic Chemistry, Madurai-Kamaraj University, Madurai, May 1985

Post doctoral studies: August 1990-February 1992, Suntory Institute for Biorganic Research, Osaka, Japan under the gudance of Dr. Yasufumi Ohfune. Synthesis of rigid glutamic acid analogs.

March 1992-March 1994, Department of Chemistry, University of Montreal, Montreal, Canada under the supervision of Prof. Stephen Hanessian. Synthesis of a prototype renin inhibitor.

Employment

Scientist at Hoechst India Ltd. May 1994 to July 1996.

IICT, October 2009 to Present Scientist F/Senior Principal Scientist



Research Interests

Present Research

Asymmetric Organic Synthesis. Research in the group is focussed toward the synthesis of natural and synthetic bioactive molecules using catalalytic asymmetric protocols employing novel methodologies, reagents and reactions. Sulfoxides, sulfilimines (nitrogen counterpart of sulfoxides) are advantageously employed as intramolecular nucleophiles for the vicinal functionalization of alkenes to prepare chiral synthons. Recently α-chloro sulfides have been utilized as reactive intermediates in C-C bond forming reactions as a route to 1,4-diols, 1,4-amino alcohols etc.

Past Research

As a research scholar I was involved in the synthesis of a complex heptacyclic natural product morellin. Model studies were carried out to synthesize the tricyclic core and xanthene residues. Cyclohexadienes prepared by metal-ammonia reuction of aromatic substrates were utilized for this research.

Projects Involved

Received funding from DST for five G. A. P thus far. Involved as a team member in projects sponsored by GSK and ArQule.



Research Group Members

  1. Dr. A. Rajender
  2. Dr. Ramakrishna Reddy
  3. Dr. A. Tony
  4. Dr. Sudheer Babu
  5. Dr. Ganapathy Subramanian



Publications

  1. Stereoselective bromohydrin formation from -hydroxy sulfoxides mediated by the pendant sulfoxide. S. Raghavan, M. A. Rasheed, S. C. Joseph and A. Rajender. Chem. Commun., 1999, 1845.
  2. Target alcohol/phenol release by cyclative cleavage using glycine as a safety catch linker. S. Raghavan and A. Rajender. Chem. Commun. 2002, 1572.
  3. Novel, convergent and stereospecific synthesis of (+)-preussin. S. Raghavan and M. Abdul Rasheed. Tetrahedron 2003, 59, 10307.
  4. Asymmetric synthesis of the potent HIV-Protease inhibitor, nelfinavir. S. Raghavan, V. Krishanaiah and B. Sridhar. J. Org. Chem. 2010, 75, 498.
  5. Highly stereoselective preparation of chiral –substituted sulfides from –chloro sulfides via 1,2–asymmetric induction. S. Raghavan, V. V. Kumar and L. R. Chowhan. Synlett 2010, 1807.



Lectures

  1. “Diastereoselective synthesis of corformationally constrained L-glutamate analogs”. S. Raghavan, K. Shimamoto and Y. Ohfune. Presented as an oral communication at the 5th International Kyoto conference on New Aspects of Organic Chemistry, Kyoto, November 11 – 15, 1991.
  2. Parallel synthesis and Combinatorial Libraries”. S. Raghavan. Presented a talk at the Workshop on Development in Drugs and Pharmaceutical Technology, Hyderabad, Nov. 6-10, 2001.
  3. Oxidative Functionalization of Alkenes Promoted by a Pendant Sulfinyl Moiety. S. Raghavan. Presented a talk at the Symposium on “Current Trends in Organic Synthesis” at Indian Institute of Science, Bangalore on 20th Nov. 2008.
  4. Stereoselective Preparation of 1,2-, 1,3-Amino Alcohol Synthons and their Application in Organic Synthesis. Presented a Talk at the “4th INSA-KOSEF Symposium in Organic Chemistry” at National Chemistry Laboratory held on 12th to 13th January 2009.
  5. Stereoselective Synthesis of 1,2-, 1,3-Amino Alcohol Synthons and their Application in Organic Synthesis. Presented a Talk at Dr. Reddy’s Research Foundation, Hyderabad on 31st August 2009.



Awards

  1. B. H. Iyer Best Thesis Award Medal 1990
  2. C. V. Raman Fellowship 2005





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