Dr.Chandrasekhar S
Director
CSIR-Indian Institute of Chemical Technology                             
(Council of Scientific and Industrial Research)
Ministry of Science & Technology, Government of India
Tarnaka, Hyderabad-500007, Telangana, INDIA

Landline 27193030
Mobile 9440802787
Fax
Email ID director@iict.res.in
Alternate Email ID srivaric@iict.res.in
Alternate URL http://www.iictindia.org/staffprofiles/staffProfile.aspx?emp_id=iict1372

Bibliography

About

Dr Srivari Chandrasekhar is an excellent synthetic organic chemist and this is amply justified by 258 publications, 3 patents and ~5000 citations in various journals. His contributions in total synthesis of scarce marine natural products and organocatalysis are globally recognized.

His noteworthy contributions in the total synthesis of architecturally diverse natural products are well-reflected towards the total synthesis of 35 natural products, which include an acinar morphogenetic inhibitor, Fusarisatin A, molecule with anticancer activity through tubulin inhibition, Rhazinal, neuro-protective natural product Stachybotrin C, anticancer molecule pladienolide, molecule with CNS activity, Kainic acid, prostacyclin analogue Beraprost, Bedaquiline (both R and S isomers) anti-TB compound, Azumamide E, Bengazole, Arenamide, Tubulysin, Spirastellolide B, Hyacinthacene A1, (-)-Spongidepsin with absolute stereo control. All these achievements were accomplished while developing new C–C bond formation reactions using organo-catalysis and carbocycles derived from carbohydrates.

More prudent research field has been the identification of novel peptido-mimetics wherein research group of Dr. S. Chandrasekhar has synthesized β-sugar amino acids, norbornene-based, aminoxy acids of furanoses and nucleoside-based amino acids and demonstrated that these monomers in various combinations of oligomerization resulted in predefined secondary structures including nanotubes.

Dr S. Chandrasekhar has for the first time identified polyethylene glycol (PEG) as a recyclable solvent for organo-metallic reactions wherein both the solvent and catalyst can be recycled. This unprecedented report triggered various research programs using PEG as a solvent in different parts of the world. Some of the reactions worth mentioning using PEG as solvent are as follows: Heck reaction in PEG, Sharpless asymmetric dihydroxylation (was performed for the first time in PEG), PtO2 recycle and H2 absorption studies. This work has found direct applications in developing non-infringing technologies for APIs.

Dr S Chandrasekhar has never hesitated to take-up challenging process development subjects relevant to health care. The processes developed for semi-synthesis of Taxol (M/s. Cipla), Misoprostol (M/s. AVRA) and Carboprost (M/s. AVRA) are worth mentioning and biotech problems are also addressed by him as evident in the synthesis of Fondaparinux as anti-coagulant agent (Table 1). In addition, as part of the ‘Drug Discovery Process,’ over 500 new chemical entities are being synthesized in his group. The process developed for EV-077 sponsored by M/s. Evolva biotech helped them to enter into phase I clinical studies.

Several combinatorial libraries were prepared in his group as new chemical entities for screening against cancer (US patent 7179937), TNFα, 5HT antagonism etc. Two review articles written by him on hybrid natural products (Angewandte Chemie 2003, 3996) and prostaglandins (Chemical Review, 2007, 3286) are worth mentioning. A recent contribution of Dr. S. Chandrasekhar is the synthesis of bedaquiline (2S)-R207910, a novel anti-tuberculosis molecule, which has appeared as cover page with theme “Chemistry for a healthy world” in Eur. J. Org. Chem. 2011, 2057.

To date 50 students have already been awarded doctoral degree under his supervision and 20 students are pursuing their doctoral work on various themes in total synthesis, green chemistry, supramolecular chemistry, automation combinatorial chemistry and chemical biology.

Education

Alexander von Humboldt Fellow in Organic Chemistry during 2001 from University of Goettingen, Germany;

Post Doctoral studies in Organic Chemistry during 1991-1994 from UT Southwestern Medical Center, Dallas, TX

Ph.D in Organic Chemistry during 1991 from Osmania University

(work done at IICT, Title:Synthesis of Some Biologically Active Compounds; Supervisor: Dr. A. V. Rama Rao, D. Sc., FNA, FTWAS)

M.Sc in Organic Chemistry during 1985 from Osmania University

B.Sc in Botany, Zoology, Chemistry during 1982 Osmania University

Employment

Junior Research Fellow from 1986 to 1988 at Indian Institute of Chemical Technology, Hyderabad;

Senior Research Fellow from 1988 to 1991 at Indian Institute of Chemical Technology, Hyderabad;

Post Doctoral Fellow from 1991 to 1994 at University of Texas, South western Medical Center, Dallas, USA;

Scientist C from 1994 to 1999 at Indian Institute of Chemical Technology, Hyderabad;

Scientist EI from 1999 to 2004 at Indian Institute of Chemical Technology, Hyderabad;

Alexander von Humboldt Fellow from 2000 to 2001 at University of Goettingen, Germany;

Scientist EII from 2004 to 2005 at Indian Institute of Chemical Technology, Hyderabad;

Scientist F from 2005 to 2010 at Indian Institute of Chemical Technology, Hyderabad;

Scientist G, Chief Scientist from 2010 to 2015 at Indian Institute of Chemical Technology, Hyderabad;

Director, from June 2015 at Indian Institute of Chemical Technology, Hyderabad;



Research Group Members

  1. Dissertations supervised -
  2. Ph.D Students : 50
  3. Post Graduation : 35

Publications

  1. Enantioselective synthesis of Pladienolide B and truncated analogues as new anti-cancer agents V Praveen Kumar and S. Chandrasekhar* Organic Letters 2013, 15, 3610-3613
  2. Formal Synthesis of Anti-Platelet Drug, Beraprost N. Kesava Reddy, B. V. D. Vijaykumar and S. Chandrasekhar* Organic Letters 2012, 14, 299-301
  3. Total Synthesis of Bengazole A S. Chandrasekhar,* and A. Sudhakar Organic Letters 2010, 12, 236-238
  4. Polyethylene glycol (400) as superior solvent medium against ionic liquids for catalytic hydrogenations with PtO2 S. Chandrasekhar,* S. Jaya Prakash and Ch. Lohitha Rao J. Org. Chem. 2006, 71, 2196-2199
  5. Expanding the Conformational Pool of cis-β-Sugar Amino Acid: Accommodation of β-hGly Motif in Robust 14-Helix S. Chandrasekhar,* M. Srinivasa Reddy, B. Nagendra Babu, B. Jagadeesh, A. Prabhakar and B. Jagannadh. J. Am. Chem. Soc. 2005, 127, 9664-9665

Patents

  1. International patent, Gurjar, Mukund K.; (Pune, IN) ; Wakharkar, Radhika D.; (Pune, IN) ; Desiraju, Gautam R.; (Hyderabad, IN) ; Nangia, Ashwini; (Hyderabad, IN) ; Yadav, J. S.; (Hyderabad, IN) ; Burman, Anand C.; (Ghaziabad, IN) ; Mukherjee, Rama; (Ghaziabad, IN) ; Borate, Hanumant Bapurao; (Pune, IN) ; Chandrasekhar, Srivari; (Hyderabad, IN) ; Jaggi, Manu; (Ghaziabad, IN) ; Singh, Anuo T.; (Ghaziabad, IN) ; Kapoor, Kamal K.; (Ghaziabad, IN) ; Sarkhel, Sanjay; (Hyderabad, IN) ; Sairam, Kalapatapu V.V.M.; (Hyderabad, IN) US 7179937. Cyclopentenone derivatives for cancer therapy.
  2. Saibal Das, Rene Gree, J. S. Yadav, S. Chandrasekhar, P Srihari and A.V. Rama Rao. (Application no:1530/CHE/2007, Filing date: 16.07.07, Indian patent filed). Process for enzymatic resolution of racemic monosubstituted cis-2-cycloalkene-1,4-diols in ionic liquids.
  3. S.Chandrasekhar, T. Pavan Kumar, Vidyavathi Patro and Ch. Rajireddy. (Patent submitted to IICT IPM Division). Novel triazoles andoxime ethers from hydroxylamine derivatives.



Lectures

  1. "Stereo-control in Claisen Rearrangement: Applications in Products of Human Health Care" Invited lecture 'RMIT-in India-Beyond 2013' RMIT University, Melbourne, Australia, December 4th, 2013
  2. "Synthesis of Heterocyclic Natural and non-Natural products in human well being" ENCPS Chimie Paristech, 20 September 2012
  3. "Synthesis of Heterocyclic Natural and non-Natural products in human well being" Max Plank Institute, Germany,13 September 2012
  4. "The Role of Synthetic Organic Chemist in Human Health Care", Invited lecture, Lecture Workshop, Telangana University-Dept. of Pharmaceutical Chemistry, 5th Feb 2015
  5. "The Role of Synthetic Organic Chemist in Human Health Care", Invited lecture Prof. A Srikrishna Memorial Lecture Series, 'Organic Synthesis', 20th Jan 2015

Awards

  1. Infosys Prize 2014 in Physical Sciences; Work in Organic Synthesis; Infosys Science Foundation; 2014
  2. CSIR Technology Award; Process for Misoprostol; Council of Scientific and Industrial Research; 2014
  3. CNR Rao National Prize for Chemical Research; Work in Organic Synthesis; CRSI; 2012
  4. OPPI Scientist Award; Work in Pharmaceutical Sciences; OPPI, Mumbai; 2011
  5. Ranbaxy Research Award; Work in Pharmaceutical Chemistry; Ranbaxy; 2010

Honours

  1. Fellow, Indian National Science Academy; Work in Organic Synthesis; Indian National Science Academy; 2015
  2. Fellow, National Academy of Sciences; Work in Organic Synthesis; National Academy of Sciences, Allahabad; 2010
  3. Fellow, Indian Academy of Sciences; Work in Organic Synthesis; Indian Academy of Sciences, Bangalore; 2010
  4. Fellow of Andhra Pradesh Akademi of Sciences; Work in Organic Synthesis; A. P. Akademi of Sciences; 2006
  5. Diamond Jubilee Roll of Honor; Chemical Sciences;IICT; 2005



© 2014 CSIR-IICT, Tarnaka, Hyderabad - 500007, India. Ph: 91-40-27191234