Dr.Radha Krishna P
Chief Scientist
CSIR-Indian Institute of Chemical Technology                             
(Council of Scientific and Industrial Research)
Ministry of Science & Technology, Government of India
Tarnaka, Hyderabad-500007, Telangana, INDIA

Landline 27193158
Mobile 9848555242
Fax
Email ID prkgenius@iict.res.in
Alternate Email ID radhakrispal@gmail.com
Alternate URL

Bibliography

About

Twenty three years (after Ph.D.) of research experience on the synthesis of enantiomerically pure compounds.Worked on the projects involving researchers from both domestic and overseas pharma/biotech companies.Design and synthesis of New Chemical Entities for New Drug Discovery process.Creativity in problem solving: Identification/Development of novel synthetic routes/ processes for candidate molecules adopting non-patent infringing routes

Expertise in diverse areas of organic synthesis: Aromatics, Carbohydrates, Aliphatic chemistry, Asymmetric synthesis (both by ‘chiron’ approach or chiral catalyst assisted), Design and synthesis of fluorescently labeled analogs of Epothilone B and Baccatin derivatives, C-nucleosides etc.

To my Credit total are: Ph. D.s: 22-completed (10-working), MS: 14, Publications: 147, US Patents 14, Indian Patents: 2, Book Chapters-3, Reviews-4

Education

1) B Sc. in 1981 (First Class) with Botany, Zoology and Chemistry from OSMANIA UNIVERSITY and Obtained STATE MERIT Scholarship.

2) M. Sc. (Chemistry) in 1983 from OSMANIA

UINVERSITY with DISTINCTION.

3) Ph. D in ORGANIC CHEMISTRY in 1989 from PUNE

UNIVERSITY

Employment

1990-1992 Research Associate, CSIR-Indian Institute of Chemical Technology, Hyderabad;

1992-1997 Jr. Scientist, CSIR-Indian Institute of Chemical Technology, Hyderabad;

1997-2001 Scientist, CSIR-Indian Institute of Chemical Technology, Hyderabad;

2001-2004 Sr. Scientist, CSIR-Indian Institute of Chemical Technology, Hyderabad;

2004-2009 Principal Scientist, CSIR-Indian Institute of Chemical Technology, Hyderabad;

2009-Present Sr. Principal Scientist, CSIR-Indian Institute of Chemical Technology, Hyderabad.

Research Interests

Present Research

1)Synthesis of Natural Product

2)Carbohydrate Mimetics

3)Asymmetric Baylis-Hillman reaction

4)Synthetic Methodologies

5)Organocatalysis

6)New Drug Discovery

Past Research

Baylis-Hillman reaction

Natural Product Synthesis

Projects Involved

1). 1997-1999 CytoMed/Leukosite (USA) - New Routes to 5-LO inhibitors worked as Project Leader.

2). 1998-1999 SmithKline Beecham (UK) - Solid Phase Org. Chem. worked as Project Leader.

3). 1999-2000 SmithKlineBeecham (UK) - Process route to SB214857 worked as Project Leader.

4).2000-2001 SmithKline Beecham (UK) - Novel Scaffolds worked as Project Leader.

5).2002-2003 ArQule (USA) - Solution Phase Org. Chem worked as Project Leader.

6).2007-2010 DST (India)-New Chiral Amine based catalysts

for enantioslective Baylis-Hillman Reaction. Principal Investigator.

7).2002-2007 CSIR - Asthma and allergic disorders mitigation mission. Worked as Co-Investigator.

8).2007-2012 CSIR - Diagnostics for allergy, bronchial asthma and COPD. Worked as Co-Investigator.

9).2008-Onwards. Indo-French Joint Laboratory for Sustainable Chemistry at Interfaces. Working as Collaborative Scientist.

10).2012-Onwards CSIR-IICT-RMIT Collaborative Project. Working as Collaborative Scientist.

11).2013-Onwards OSDD program, Design and synthesis of NCEs. Working as Principal Investigator.

13).2012- Onwards CSIR - Therapeutics of Chronic Obstructive Pulmonary

Diseases (COPD) and Related Respiratory Disorders (TREAT). Working as Nodal Scientist.

14).2012-onwards ORIGIN, COORDINATING LAB CSIR-IICT (CHEMICAL CLUSTER PROJECT). Working as a Participating Scientist



Research Group Members

  1. Dr Sudhir Kashyap, Inspire faculty, OBC Division
  2. Mr. K Rajesh
  3. Mr. S Prabhakar
  4. Mr. M V Satyanarayana
  5. Mr. T Srinivas



Publications

  1. Radha Krishna, P.; Rachna Sachwani, Kannan, V. “Double Asymmetric Induction’ as a novel tool for high stereocontrol in Baylis-Hillman reaction”, Chem. Commun.; 2004, 2580-2581. (IF 6.169; cit. 18)
  2. Radha Krishna, P.; Kannan, V.; Sharma G V M. “First diastereoselective intramolecular Baylis-Hillman reaction: An easy access to chiral alpha-methylene-beta-hydroxylactones”, J. Org. Chem. 2004, 68, 6467-6469. (IF 4.450; cit. 26)
  3. Radha Krishna, P.; Kannan, V.; Narasimha Reddy, P. V. “N-Methyl Prolinol Catalyzed Asymmetric Baylis-Hillman Reaction”, Adv. Synth. & Catal. 2004, 346(6), 603-606. (IF 6.048; cit. 49).
  4. Radha Krishna, P.; Jaggannadha Rao, T.”Total synthesis of decarestrictine I and botyrolide B via RCM protocol. Org. Biomol. Chem. 2010, 8, 3130-3132. (IF 3.696; cit. 7).
  5. Radha Krishna, P.; Venkata Ramana, D. Titanium(IV)-Promoted Regioselective Nucleophilic Ring-Opening Reaction of Chiral Epoxyallyl Alchols with Acids as a Tool for Ready Access to Chiral 1,2,3-Triol Monoesters: Application to Stereoselective Total Synthesis of Macrolides. J. Org. Chem. 2012, 77, 674-679. (IF 4.450)



Patents

  1. Substituted Oxygen Alicyclic Compounds, Including Methods for Synthesis Thereof. US Patent No. 6,306,895 (23 October 2001), EP1094805A1 (May 2, 2001). M S Chorghade, M K Gurjar, Palakodety Radha Krishna, S V S Lalitha, K Sadalapure, S S Adhikari, A M S Murugaiah, S V Mhaskar, G V M Sharma, T Rajendra Prasad, P Sreenivas, V Goverdhan Reddy, B Sridhar Reddy, L Hymavathi, Aminul Islam, C Hariprasad, A V Rama Rao, B V Rao and L Murali Krishna.
  2. Methods for Synthesis of Substituted Tetrahydrofuran Compound. US Patent No. 6,310,221 (30 October 2001), EP1102759A1 (May 30, 2001). M S Chorghade, M K Gurjar, Palakodety Radha Krishna, S V S Lalitha, K Sadalapure, S S Adhikari, A M S Murugaiah, S V Mhaskar, G V M Sharma, T Rajendra Prasad, P Sreenivas, V Goverdhan Reddy, A Islam, C. Hari Prasad and A V Rama Rao.
  3. Substituted Oxygen Alicyclic Compounds, Including Methods for Synthesis Thereof. US Patent No. 6,566,538 (May 20, 2003). M S Chorghade, M K Gurjar, Palakodety Radha Krishna, S V S Lalitha, K Sadalapure, S S Adhikari, A M S Murugaiah, B V Rao, L Murali Krishna, S V Mhaskar, G V M Sharma, T Rajendra Prasad, P Sreenivas, V Goverdhan Reddy, Aminul Islam, A V Rama Rao, L Hymavathi, B Sridhar Reddy, C Hariprasad.
  4. Novel non-natural C-linked carbo-beta-peptides with robust secondary structures US2004192885 (30 Sept. 2004) G V M Sharma, K Ravinder Reddy, Palakodety Radha Krishna, Jayaprakash, A Ravi Sankar, B Jagannadh and A C Kunwar
  5. Synthetic phosphodiesterase 4 inhibitor with antiasthmatic activity, 175/DEL/2010 (29 January, 2010) G V M Sharma, J S Yadav, P Radha Krishna, A. Bandyopadhyay, S Roy, S Bandyophayay, R K Johri, S C Sharma, B. Ghosh, M Ulaganathan, S Balwani, B Paul, A K Saxena.



Lectures

  1. Palakodety Radha Krishna, Invited talk on, “Total synthesis of Natural products from Chirons” POSTECH, Pohang, South Korea, September 7, 2005.
  2. Palakodety Radha Krishna, Invited lecture on, “Sugar-derived aldehydes as chiral templates in the synthesis of diverse combi-libraries” at 2006 International Symposium on Chemical Biology and Combinatorial Chemistry, Shandong, Jinan, China, December 28-30, 2006
  3. Palakodety Radha Krishna, Invited lecture on, “New Facets of Chiral Aldehydes in Organic Synthesis: Some Glimpses” at First One-Day Symposium under Indo-French Joint Laboratory for Sustainable Chemistry at Interfaces, IICT, Hyderabad, India, 21st July, 2008.
  4. Palakodety Radha Krishna, Invited lecture on, “Metathesis in Natural Product Synthesis” at ASOMPS-XIII, IICT, Hyderabad, India, November 3-6, 2008.
  5. . Palakodety Radha Krishna, Invited Lead Lecture on, “The Art of Organic Synthesis” at First AP Science Congress, Osmania University, Hyderabad, India, November 14-16, 2008.



Awards

  1. Best Innovator Award, Ms. CytoMed Inc. US, 1999
  2. Associate Fellow, Andhra Pradesh Akademy of Sciences, Hyderabad, 2003
  3. Fellow of Royal Society of Chemists (London); UK, 2012
  4. Fellow of A P Akademy of Sciences, Hyderabad. 2012





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